Yi Qiu, Ph.D., Assistant Professor in the Department of Anatomy and Cell Biology, recently co-authored an article published in the newest issue of Cell Reports titled “HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development”.
Dr. Qiu stated, “In collaboration with Dr. Suming Huang from the Department of Biochemistry and Molecular Biology, we show that HoxBlinc lincRNA specifies hemangiogenic/cardiogenic mesoderm and promotes hematopoietic development by upregulating hoxb gene expression. HoxBlinc acts as a regulator of chromatin loop structure by guiding Setd1a/MLL1 to hoxb genes to control lineage-specific transcription.”
To read the full Cell Reports article click here