Paul J. Linser, Ph.D.

Paul Linser, Ph.D.Professor

Office: Whitney Marine Laboratory
Email: pjl@whitney.ufl.edu
Phone: (904) 461-4036
Fax: (904) 461-4052


Education and Training

Ph.D. – (Developmental Biology) University of Cincinnati (1977)
B.S. – (Biology) University of Cincinnati (1974)

Research Interests

I was trained as a Developmental Biologist and my broad interests focus on regulation of genes that serve to distinguish and define specific cell types in maturing tissues. My coworkers and I have defined a number of specific gene products that define cells of the vertebrate neural retina. One such gene product is the enzyme Carbonic Anhydrase which is expressed specifically by the glial cells of the retina. Other gene markers for the glial cells have been utilized in analyses of the regulation of cell phenotype maturation. My expertise with Carbonic Anhydrase has also drawn me into a project which focuses on the biology of disease vector mosquitoes and in particular larval molecular physiology. Our recent investigations have shown that mosquitoes possess as many as 14 Carbonic Anhydrase genes which are differentially expressed. Currently we are building a comprehensive physiological model of larval mosquito gut function in relation to its relatively unique alkaline digestive strategy. Mosquitoes are the number one threat to human health according to the World Health Organization with Malaria alone killing 3,000 children per day. Hence our investigations of larval mosquito biology have the potential to generate new control strategies and to help alleviate the burden of diseases vectored by mosquitoes.

Research Projects

Our lab is pursuing two very different projects. The first is aimed at delineating molecular mechanisms that regulate gene cell development in the vertebrate neural retina. The second project focuses on the molecular physiology of the alkaline gut of the mosquito larva.

Whitney Marine Laboratory
The Whitney Laboratory, founded in 1974, is a research institute of the University of Florida. The mission of the Laboratory is to use marine organisms in basic biological research and to apply the results to problems of human health, natural resources and the environment. The Whitney Lab trains future experimental biologists, contributes to public education and helps formulate policy in basic research and marine science.
http://www.whitney.ufl.edu

References

Linser, P.J., Peterson, R.E., McClilntock, J., Possley, J. and Orozco, A. The regulation of ller cell differentiation: focus on the definitive ller cell markers glutamine synthetase and carbonic anhydrase-II. J. Brain Res. 37:213-214, 1996.

Linser, P.J. Cell-cell interactions as a target for teratogenic events. In: Drug Toxicity in Embryonic Development. R. Kavlock and G. Daston (eds.) Handb. Exp. Phar. 124:277-300, 1996.

Fadool, J.M. and Linser, P.J. Evidence for the formation of multimeric forms of the 5A11/HT7 antigen. Biochem. Biophys. Res. Com. 229:280-286, 1996.  Pubmed

Peterson, R.E., Tu, C. and Linser, P.J. Isolation and characterization of a carbonic anhydrase homologue from the zebrafish (Danio rerio). J. Mol. Evol.44:432-439, 1997.  Pubmed

Linser, P.J., Schlosshauer, B., Galileo, D.S., Buzzi, W.R. and Lewis. R. Late proliferation of Müller cell progenitors facilitates preferential targetting with retroviral vectors in vitro. Develop. Genetics. 20:186-196, 1997.  Pubmed

Linser, P.J. Thyroid hormone influences carbonic anhydrase-II expression in embryonic retina. Bol. Med. Biol. 44:57-58, 1997.

Linser, P.J. Trapido-Rosenthal, H.G. and Orona E. Glutamine synthetase is a glial-specific marker in the olfactory regions of the lobster (Panulirus argus) nervous system. Glia20:275-283, 1997.  Pubmed

Orozco, A., Linser, P.J. and Valverde-R, C. Salinity modifies hepatic outer-ring deiodination (ORD) activity in Fundulus heteroclitus. Ann. N.Y. Acad. Sci.839:409-411, 1998  Journal

Linser, P.J., Carr, W.E.S., Cate, H.S., Derby, C.D. and J.C. Netherton III. Functional significance of the co-localization of taste buds and teeth in the phayngeal jaws of the largemouth bass, Micropterus salmoides. Biol. Bull.195:273-281, 1998.  Pubmed

Skeith, A., Dunlap, L., Galileo, D.S. and Linser, P.J. Inhibition of β1-integrin expression reduces clone size during early retinogenesis. Develop. Brain Res.116:123-126, 1999.  Pubmed

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