GMS 6062 – Protein Trafficking

Course Director

John P. Aris PhD, Associate Professor, Department of Anatomy and Cell Biology
Contact information:, 352-273-6868. Office: Rm D2-32A (Dental Science Bldg).


Students must have successfully completed Fundamentals of Biomedical Sciences I (GMS 6001) or obtained permission from the course director.


This course focuses on the current state of knowledge protein movements in eukaryotic cells. The course will emphasize molecular mechanisms and disease processes related to protein targeting.

Topic Area Examples

ER protein translocation, protein folding, and protein quality control
Vesicular transport mechanisms (e.g., vesicle formation and targeting)
Golgi apparatus structure and function (e.g., models and predictions)
Protein import into mitochondria, peroxisomes, and/or the nucleus
Endocytosis and endosome trafficking (e.g., signaling receptors)
Lysosomal targeting and homeostasis, including autophagy


Reading assignments are posted at the course web page in Canvas. Students are encouraged to suggest papers for class. There are no required textbooks, but textbooks may be helpful for review.

Learning Objectives

Identify cutting edge topics in the current literature related to protein trafficking.

  1. Identify cutting edge topics in the current literature related to protein trafficking.
  2. Discuss current hypotheses related to mechanisms and functions of protein trafficking.
  3. Critically examine experimental approaches pertinent to understanding protein trafficking.
  4. Critically evaluate experimental data germane to understanding protein trafficking.


Classes will consist of either a brief introductory lecture followed by discussion of assigned readings or presentations by students of readings chosen in advance by the student and the course director.