Course Director
John P. Aris PhD, Associate Professor, Department of Anatomy and Cell Biology
Contact information: johnaris@ufl.edu, 352-273-6868. Office: Rm D2-32A (Dental Science Bldg).
Prerequisites
Students must have successfully completed Fundamentals of Biomedical Sciences I (GMS 6001) or obtained permission from the course director.
Overview
This course focuses on the current state of knowledge protein movements in eukaryotic cells. The course will emphasize molecular mechanisms and disease processes related to protein targeting.
Topic Area Examples
ER protein translocation, protein folding, and protein quality control
Vesicular transport mechanisms (e.g., vesicle formation and targeting)
Golgi apparatus structure and function (e.g., models and predictions)
Protein import into mitochondria, peroxisomes, and/or the nucleus
Endocytosis and endosome trafficking (e.g., signaling receptors)
Lysosomal targeting and homeostasis, including autophagy
Assignments
Reading assignments are posted at the course web page in Canvas. Students are encouraged to suggest papers for class. There are no required textbooks, but textbooks may be helpful for review.
Learning Objectives
Identify cutting edge topics in the current literature related to protein trafficking.
- Identify cutting edge topics in the current literature related to protein trafficking.
- Discuss current hypotheses related to mechanisms and functions of protein trafficking.
- Critically examine experimental approaches pertinent to understanding protein trafficking.
- Critically evaluate experimental data germane to understanding protein trafficking.
Format
Classes will consist of either a brief introductory lecture followed by discussion of assigned readings or presentations by students of readings chosen in advance by the student and the course director.