Dorina Avram, PhD

davramPreeminence Professor
Associate Chair

Office: BSB B1-006
Email: davram@ufl.edu
Phone: (352) 273-8474

Avram Lab


Education and Training

PhD – Genetics, Oregon State University

Postdoctoral Training

Postdoctoral Fellow – Molecular Pharmacology, Oregon State University College of Pharmacy

 

Research Interests

  • Epigenetic and transcriptional control in immune responses – impact on immune homeostasis and autoimmune diseases
  • Harnessing the immune responses for cancer therapies
  • Ubiquitin ligases in multiple sclerosis and neuro-inflammation
  • Ubiquitin ligases in inflammatory bowel diseases and colon cancer
  • New therapies for multiple sclerosis

Active Grants

  • R01 AI133623 (NIH/NIAID) (multi-PI Keselowsky, Avram) 2017-June 2022, Tolerogenic dual microparticle system for treatment of multiple sclerosis
  • R01 AI067846-12 (NIH/NIAID) (Avram, PI) 2019-2024, Bcl11b in CD4+ T cells and innate lymphoid cells

 

Professional Societies

American Association of Immunologists

Honors and Awards

FEBS Fellowship 1990
NATO Fellowship 1991
IREX Fellowship 1992
Soros Foundation Fellowship 1993
American Society for Enology and Viticulture Fellowship 1993-1996
K01 Career Developmental Award, National Institute of Health, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Arthritis Branch 2001-2006
American Cancer Society Research Scholar 2004-2009

 

References

Danielle Califano, Jonathan J. Cho, Qi Yang, Avinash Bhandoola, Hongmin Li and Dorina Avram. Transcription factor Bcl11b controls identity and function of mature innate lymphoid cells type II. Immunity. 2015 Aug 18;43(2):354-68. | PubMed

Erin Y. Harmon, Van Fronhofer, III, Rebecca S. Keller, Paul J. Feustel, Xinmei Zhu, Hao Xu, Dorina Avram, David M. Jones, Shanmugam Nagarajan and Michelle R. Lennartz. Anti-inflammatory Immune Skewing is Atheroprotective: Apoe-/-Fc?RIIb-/- Mice Develop Fibrous Carotid Plaques. J Am Heart Assoc. 2014 Dec 16;3(6). pii: e001232. | PubMed

Dorina Avram & Danielle Callifano. The multifaceted roles of Bcl11b in thymic and peripheral T cells – impact on immune diseases. J Immunol. 2014 Sep 1;193(5):2059-2065. | PubMed

Mohammad Uddin, Yubin Zhang, Jonathan Harton, Katherine MacNamara, Dorina Avram. TNF-a-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. J Immunol. 2014 Feb 15;192(4):1946-53. | PubMed

Califano D, Van Valkenburgh J, Yager E, O’Connor W, Kennedy J, Avram D. Diverting Thelper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis. J Clin Invest. 2014 Jan 2;124(1):174-87. (PMID: 24316973). | PubMed

Yubin Zhang, Maura Jones, Gary M. Winslow, Dorina Avram and Katherine C. MacNamara. MyD88-Signaling in CD4 T Cells is Critical for IFNG Production and Hematopoietic Stem and Progenitor Cell Expansion in Response to Intracellular Bacterial Infection. J Immunol. 2013 May 1;190(9):4725-35. | PubMed

Van Valkenburgh J, Albu DI, Bapanpally C, Casanova S, Califano D, Jones DM, Ignatowicz L, Kawamoto S, Fagarasan S, Jenkins NA, Copeland NG, Liu P, Avram D. Critical role of Bcl11b in suppressive function of T regulatory cells and prevention of inflammatory bowel disease. J Exp Med 208(10):2069-2081, 2011. | PubMed

Zhang S, Rozell M, Albu DI, Randall T, Jenkins NA, Copeland NG, Liu P, Avram D. Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b. J Exp Med 207(8):1687-99, 2010. | PubMed

Albu DI, Jeffrey Van Valkenburgh, Nicole Morin, Danielle Califano, Jenkins NA, Copeland NG, Liu P, Avram D. Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes. Proc Natl Acad Sci USA 108(15):6211-6, 2011. | PubMed

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