Dorina Avram, PhD

davram

Preeminence Professor
Associate Chair

Office: BSB B1-006
Email: davram@ufl.edu
Phone: (352) 273-8474
Avram Lab


Education and Training

PhD – Genetics, Oregon State University

Postdoctoral Training

Postdoctoral Fellow – Molecular Pharmacology, Oregon State University College of Pharmacy

Research Interests

  • Epigenetic and transcriptional control in immune responses – impact on immune homeostasis and autoimmune diseases
  • Harnessing the immune responses for cancer therapies
  • Ubiquitin ligases in multiple sclerosis and neuro-inflammation
  • Ubiquitin ligases in inflammatory bowel diseases and colon cancer
  • New therapies for multiple sclerosis

Active Grants

  • R01 AI133623 (NIH/NIAID) (multi-PI Keselowsky, Avram) 2017-June 2022, Tolerogenic dual microparticle system for treatment of multiple sclerosis†
  • R01 AI067846-12 (NIH/NIAID) (Avram, PI) 2019-2024, Bcl11b in CD4+ T cells and innate lymphoid cells†††

Professional Societies

American Association of Immunologists

Honors and Awards

FEBS Fellowship 1990
NATO Fellowship 1991
IREX Fellowship 1992
Soros Foundation Fellowship 1993
American Society for Enology and Viticulture Fellowship 1993-1996
K01 Career Developmental Award, National Institute of Health, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Arthritis Branch 2001-2006
American Cancer Society Research Scholar 2004-2009

References

Cho JJ, Xu Z, Parthasarathy U, Drashansky TT, Helm EY, Zuniga AN, Lorentsen KJ, Mansouri S, Cho JY, Edelmann MJ, Duong DM, Gehring T, Seeholzer T, Krappmann D, Uddin MN, Califano D, Wang RL, Jin L, Li H, Lv D, Zhou D, Zhou L, Avram D. Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Nat Commun. 2019 Feb 11;10(1):701. doi: 10.1038/s41467-019-08605-3. | PubMed

Li S, Bostick JW, Ye J, Qiu J, Zhang B, Urban JF Jr, Avram D, Zhou L. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 Nov 20;49(5):915-928.e5. doi: 10.1016/j.immuni.2018.09.015. Epub 2018 Nov 13. | PubMed

Lorentsen KJ, Cho JJ, Luo X, Zuniga AN, Urban JF Jr, Zhou L, Gharaibeh R, Jobin C, Kladde MP, Avram D. Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. Nat Commun. 2018 Jul 19;9(1):2901 | PubMed

Cho JJ, Lorentsen KJ, Avram D. Signaling Mechanisms Regulating T Cell Diversity and Function. Soboloff J, Kappes DJ, editors. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. | PubMed

Cho JJ, Stewart JM, Drashansky TT, Brusko MA, Zuniga AN, Lorentsen KJ, Keselowsky BG, Avram D. An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis. Biomaterials. 2017 Oct;143:79-92. doi: 10.1016/j.biomaterials.2017.07.029. Epub 2017 Jul 24. | PubMed

Sharp SP, Avram D, Stain SC, Lee EC. Local and systemic Th17 immune response associated with advanced stage colon cancer. J Surg Res. 2017 Feb;208:180-186. doi: 10.1016/j.jss.2016.09.038. Epub 2016 Sep 28. | PubMed

Abboud G, Stanfield J, Tahiliani V, Desai P, Hutchinson TE, Lorentsen KJ, Cho JJ, Avram D, Salek-Ardakani S. Transcription Factor Bcl11b Controls Effector and Memory CD8 T cell Fate Decision and Function during Poxvirus Infection. Front Immunol. 2016 Oct 13;7:425. eCollection 2016. | PubMed

Uddin MN, Sultana DA, Lorentsen KJ, Cho JJ, Kirst ME, Brantly ML, Califano D, Sant’Angelo DB, Avram D. Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7608-13. | PubMed

Danielle Califano, Jonathan J. Cho, Qi Yang, Avinash Bhandoola, Hongmin Li and Dorina Avram. Transcription factor Bcl11b controls identity and function of mature innate lymphoid cells type II. Immunity. 2015 Aug 18;43(2):354-68. | PubMed

Erin Y. Harmon, Van Fronhofer, III, Rebecca S. Keller, Paul J. Feustel, Xinmei Zhu, Hao Xu, Dorina Avram, David M. Jones, Shanmugam Nagarajan and Michelle R. Lennartz. Anti-inflammatory Immune Skewing is Atheroprotective: Apoe-/-Fc?RIIb-/- Mice Develop Fibrous Carotid Plaques. J Am Heart Assoc. 2014 Dec 16;3(6). pii: e001232. | PubMed

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