Assistant Scientist

Office: CGRC 480E
Email: hamsathayele1@ufl.edu
Phone: (352) 273-8244

Education & Training

Ph.D. – Mahathma Gandhi University, Kerala, India (2011)
M.S. Biotechnology – Cochin University of Science and Technology, India (2002)
B.S. Zoology – Kannur University, India (1999)

Research Interests

Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells, if the spread is not controlled, it can result in death. In spite of major advancements in the field of medicine and technology, cancer still continues to be a threat to public health in the United States and other parts of the world. Prostate cancer, one of the most commonly diagnosed malignancies and the second leading cause of cancer-related deaths in American men. Patients with advanced prostate cancer are generally treated with hormonal therapies that block the function of the androgen receptor. Although these therapies are initially effective, the mortality rate increases owing to the recurrence of castration-resistant prostate cancer. Our research mainly focuses on the understanding of the CRPC progression and molecular pathways or proteins that are involved in the regulation of this transformation to castration resistant phenotype. We found that βarrestin1 regulates the androgen receptor activity under castration resistant condition which results in tumor progression and metastasis.

References

Hamsa Thayele Purayil, Yushan Zhang, Anindya Dey, Zhachery Gregsy, Laura-Espana-Serrano, Yehia Daaka. (2015): Arrestin-2 modulates androgen receptor activation. Oncogene; 34(24): 3144-51. | PubMed

Xiaojie Ma, Laura Espana-Serrano, Wan-ju Kim, Hamsa Thayele Purayil, Zhongzhen Nie, Yehia Daaka. (2014): β Arrestin-1 regulates RasGRF2 expression and Rac-mediated formation of membrane protrusion and cell motility. J Biol Chem; (19):13638-50. | PubMed

Yu Qin, Anindya Dey, Hamsa Thayele Purayil, Yehia Daaka. (2013): Maintenance of Androgen Receptor Inactivation by S-nitrosylation. Cancer Res; 73(22): 6690-9. | PubMed

Hamsa T.P, Kuttan G. (2012). Anti-angiogenic activity of Berberine is mediated through the down regulation of HIF-1, VEGF, and pro inflammatory mediators. Drug Chem Toxicol; 35(1): 57-70. | PubMed

Hamsa T.P, Kuttan G. (2012). Berberine inhibits pulmonary metastasis through down regulation of MMP in metastatic B16F10 melanoma cells. Phyto Ther Res; 26(4):568-78. | PubMed

Hamsa T.P, Kuttan G. (2012): Tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by modulating GSH and cytokine levels. Exp Toxicol Pathol 64(4):307-14. | PubMed

Hamsa TP, Kuttan G. (2011). Ipobscurine, an indole alkaloid from Ipomoea obscura, inhibits tumor cell invasion and experimental metastasis by inducing apoptosis. J Env Pathol Toxicol Oncol; 30(2): 163-178. | PubMed

Hamsa TP, Kuttan G. (2011). Inhibition of invasion and experimental metastasis of murine melanoma cells by Ipomoea obscura (L.) is mediated through the down-regulation of inflammatory mediators and matrix-metalloproteinases. J Exp Ther Oncol; 9(2): 139-51. | PubMed

Hamsa TP, Thejass P, Kuttan G. (2011). Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells. Drug Chem Toxicol; 34 (3):332-40. | PubMed

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